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DR. ZANE B. ANDREWS
Zane B. Andrews, Ph.D. is principal investigator in the metabolic
neurosciences
group in the Department of Physiology at Monash University in Melbourne
Australia.
Zane completed his Ph.D. at the University of Otago in New Zealand
before heading to Yale University to work with Professor Tamas Horvath.
At Yale, he discovered a novel mitochondrial signaling modality linking
mitochondrial metabolism to the regulation of food intake and body
weight. This worked published in Nature shows that key appetite control
cells in the human brain degenerate over time, causing increased hunger
and potentially weight-gain as we grow older.
He found that appetite-suppressing cells are attacked by free
radicals after eating and said the degeneration is more significant
following meals rich in carbohydrates and sugars.
"The more carbs and sugars you eat, the more your appetite-control cells
are damaged, and potentially you consume more," Zane said.
He is now located at Monash University in Australia where he is focusing
on the interaction between metabolic hormones and mitochondrial
metabolism in neuronal function and dysfunction. His specific aims are
to understand how the nervous system contributes to obesity and how long
term obesity affects neurodegeneration and neurological disorders.
Zane authored
Neuroendocrine Regulation of Prolactin Secretion During Late
Pregnancy:
Easing the Transition into Lactation and
coauthored
Uncoupling Protein-2 Is Critical for Nigral Dopamine Cell
Survival in a Mouse Model of Parkinson's Disease,
Ghrelin modulates the activity and synaptic input organization of
midbrain dopamine neurons while promoting appetite,
Dissociation of Prolactin Secretion from Tuberoinfundibular
Dopamine Activity in Late Pregnant Rats,
A Central Thermogenic-like Mechanism in Feeding Regulation: An
Interplay
between Arcuate Nucleus T3 and UCP2, and
Uncoupling protein 2 protects dopaminergic neurons from acute
1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity.
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