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Category: chemistry

Creating less trippy, more therapeutic ‘magic mushrooms’

Psilocybin—the psychoactive compound in “magic mushrooms”—is gaining scientific attention for its potential in treating neuropsychiatric conditions including depression, anxiety, substance use disorders and certain neurodegenerative diseases. However, its hallucinogenic effects may limit broader therapeutic applications. Researchers publishing in the Journal of Medicinal Chemistry synthesized modified versions of psilocin, the active form of psilocybin, that retained its activity while producing fewer hallucinogenic-like effects than pharmaceutical-grade psilocybin in a preliminary study in mice.

“Our findings are consistent with a growing scientific perspective suggesting that psychedelic effects and serotonergic activity may be dissociated,” says Andrea Mattarei, a corresponding author of the study. “This opens the possibility of designing new therapeutics that retain beneficial biological activity while reducing hallucinogenic responses, potentially enabling safer and more practical treatment strategies.”

Mood disorders and some neurodegenerative diseases, such as Alzheimer’s disease, involve imbalances of the neurotransmitter molecule serotonin, which helps regulate mood and other brain functions. For decades, scientists have been investigating the therapeutic use of psychedelics such as psilocybin on serotonin-signaling pathways. However, the hallucinations that can accompany these drugs may make people wary of taking them, even if there is a medical benefit.

Scientists discover a hidden force that helps wire the brain

Growing neurons rely on chemical cues to find their targets, but new research shows that the brain’s physical properties help shape those signals. Scientists discovered that tissue stiffness can trigger the production of guidance molecules through a force-sensing protein called Piezo1. This protein not only detects mechanical forces but also helps maintain the structure of brain tissue. The discovery reveals a powerful link between the brain’s physical environment and how its wiring is built.

Listening to the body’s quietest, yet most dynamic movements with a wearable sensor

The human body continuously generates a rich spectrum of vibrations—often without us ever noticing. Everyday unconscious activities such as breathing, speaking, and swallowing all produce subtle yet distinct mechanical signals. Although these faint vibrations carry valuable information about physiological state, they have long been difficult to capture accurately using conventional wearable devices.

Recently, a research team led by Professor Kilwon Cho of the Department of Chemical Engineering at Pohang University of Science and Technology (POSTECH), along with Ph.D. candidate Kang Hyuk Cho and postdoctoral researcher Dr. Jeng-Hun Lee, has developed a wearable vibration sensor capable of precisely detecting these subtle yet highly dynamic signals, without requiring any external power source. This breakthrough opens new possibilities for wearable medical and health care technologies and demonstrates strong potential as a core sensing platform for next-generation smart devices. The work was published in the inaugural issue of Nature Sensors.

Sounds produced by the human body span a wide range of frequencies. Physiological signals such as breathing, swallowing, and speech typically occur at lower frequencies, while sounds such as coughing or groaning emerge at relatively higher frequencies. Accurately capturing these signals requires precise detection of the minute vibrations transmitted to the skin surface across a broad frequency spectrum.

Researchers create a never-before-seen molecule and prove its exotic nature with quantum computing

An international team of scientists from IBM, The University of Manchester, Oxford University, ETH Zurich, EPFL and the University of Regensburg have created and characterized a molecule unlike any previously known—one whose electrons travel through its structure in a corkscrew-like pattern that fundamentally alters its chemical behavior. The work appears in Science.

This is the first experimental observation of a half-Möbius electronic topology in a single molecule. To the scientists’ knowledge, a molecule with such topology has never before been synthesized, observed, or even formally predicted.

Understanding this molecule’s behavior at the electronic structure level required something equally fundamental: a high-fidelity quantum computing simulation. The discovery advances science on two fronts. For chemistry, it demonstrates that electronic topology—the property governing how electrons move through a molecule—can be deliberately engineered, not merely found in nature.

Beyond amyloid plaques: AI reveals hidden chemical changes across the Alzheimer’s brain

Scientists at Rice University have produced the first full, dye-free molecular atlas of an Alzheimer’s brain. By combining laser-based imaging with machine learning, they uncovered chemical changes that spread unevenly across the brain and extend beyond amyloid plaques. Key memory regions showed major shifts in cholesterol and energy-related molecules. The findings hint that Alzheimer’s is a whole-brain metabolic disruption—not just a protein problem.

From water splitting to H₂O₂: A new method narrows carbon nitride photocatalyst design

Photocatalysis promises an efficient conversion of abundant solar energy into usable chemical energy. Polyheptazine imides have some key structural and functional twists that make them especially interesting for photocatalysis. So far, there is only limited knowledge about how structural changes affect the electronic and optical properties of the many material candidates in this class. A team led by researchers from the Center for Advanced Systems Understanding (CASUS) at HZDR has now presented a reliable and reproducible theoretical method to solve this challenge that was confirmed by measurements done on genuine candidate materials.

Polyheptazine imides belong to the family of carbon nitrides, which are layered, graphene-like compounds composed of nitrogen-rich, ring-shaped units. Unlike graphene, which exhibits excellent electrical conductivity but lacks photocatalytic activity, polyheptazine imides possess band gaps suitable for visible-light absorption.

Carbon nitride-based materials impress due to their low production cost, nontoxicity and thermal stability. However, the first generation of such materials were not ideal photocatalysts as the materials possessed properties that hindered charge separation. If a material has a low charge separation, the electron excited by an incoming photon quickly recombines with the hole it was propelled from—and releases energy only as heat or light. No energy is available to drive chemical reactions.

How the brain suppresses itch during stress

The researchers then tested whether these stress-activated neurons directly influence itch. “We ran some pilot experiments, and we saw that surprisingly, acute stress was able to suppress acute itching,” says the first author of the study.

When the team artificially activated the stress neurons, scratching behaviour decreased in both short-term chemically induced itch and a psoriasis-like chronic itch model. Conversely, when these neurons were silenced, stress no longer reduced scratching. These results showed that these neurons are both necessary and sufficient for stress-induced suppression of itch.

“We show that a specific circuit in the lateral hypothalamus can suppress itch during acute stress, revealing how the brain directly links emotional states to sensory perception,” says the corresponding author. “By identifying the specific neural circuit that links stress to itch, we are opening the possibility of targeting these brain mechanisms to better manage chronic stress-induced worsening of itch.” ScienceMission sciencenewshighlights.

Researchers have mapped a neural circuit in the brain involved in the complex relationship between itch and stress. Their findings, published in Cell Reports, reveal how specific neurons activated during stress can directly regulate itch.

Itch and pain are both unpleasant sensations triggered by harmful or irritating stimuli, but they lead to different behavioural responses. While pain typically causes us to withdraw (such as pulling our hand away from a fire), itch drives scratching. Scientists have long known that emotional states such as stress and anxiety can influence the intensity of these sensations. While the neural mechanisms linking stress and pain have been studied extensively, the effect of stress on itch has remained poorly understood.

In the new study, the team focused on the lateral hypothalamic area (LHA), a brain region known to regulate stress, motivation, and emotional states. Using genetically engineered mouse models, the researchers identified a specific population of neurons in the LHA that become active during acute stress.

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The dynamic and heterogeneous composition of biomolecular condensates and its functional relevance

Biomolecular condensates are non-membrane-encapsulated compartments that control various biological processes. Recent studies have revealed that condensates change in response to stimuli and over time. This Review discusses the heterogeneity and composition changes of nuclear and cytoplasmic condensates, their regulation and how the changes affect cellular biochemical reactions.

Inside the push to make ice rinks sustainable

Stefania Impellizzeri, a sustainable-materials chemist at Toronto Metropolitan University, is trying to make ice rinks more efficient and sustainable by fine-tuning water chemistry and rink-related materials.

Rinks use energy, water, and refrigerants, and they create microplastics. People are trying to reduce this footprint by .

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