Thought Architect

For more than a decade, Evan Economo’s lab has been using micro-CT machines to scan insect specimens. The resulting X-ray images help researchers study the form and structure of insects—a subfield of entomology known as morphology—but the process is costly and time-consuming.

“One limitation is that you can get this rich 3D dataset, but it could take 10 hours to scan one specimen,” explained Economo, who chairs the University of Maryland’s Department of Entomology and holds the James B. Gahan and Margaret H. Gahan Professorship.

As a senior author of a paper published in the journal Nature Methods, Economo tested a high-tech workflow to speed up their efforts.

Some researchers worry about risks of devaluing sign language, overreliance on imperfect devices

Brynn Bateman unveiled the New Yokosuka project.

Which should make devs a little bit happier.

Sean P. Pitroda & Ralph R. Weichselbaum provide a Commentary on Iowis Zhu et al.: https://doi.org/10.1172/JCI195652

Address correspondence to: Ralph Weichselbaum, Department of Radiation and Cellular Oncology, The University of Chicago, 5,758 S. Maryland Ave., Chicago, Illinois 60,637, USA.

Find articles by Pitroda, S. in: | Google Scholar

Department of radiation and cellular oncology, the university of chicago, chicago, illinois, USA.

Satapathy et al. demonstrate that prostaglandin E2 promotes YAP-dependent nuclear translocation of PD-L1 via importin-α3. In the nucleus, PD-L1 cooperates with YAP-TEAD to enhance transcriptional activity, revealing a noncanonical role for PD-L1 in regulating oncogenic gene expression beyond immune evasion.